Best CDMOs in United States — Ranked by Signal Score · 2026
144
CDMOs in region
89
Fully scored
39
With FDA records
99
FDA inspections
211
EMA/MHRA GMP certs
CDMO Signal tracks 144 biopharma CDMOs with confirmed United States manufacturing facilities, of which 89 are fully scored across the four-pillar composite Signal Score. Across all modalities, Charles River Laboratories, Pfizer CentreOne, and Bristol Myers Squibb (CGT Mfg) lead the United States ranking by composite score. Signal Score integrates FDA inspection history, EMA/MHRA GMP certificate density, ClinicalTrials.gov sponsor footprint, and monitored capacity signals. For modality-specific rankings within United States — AAV, cell therapy, biologics, and 10 other tracked modalities — see the modality-region breakdown below. Full methodology at cdmosignal.com/methodology.
US-based CDMOs ranked by CDMO Signal's composite Signal Score, filtered to manufacturers with confirmed United States facilities. This ranking is the subset of our global directory with US manufacturing presence — a CDMO with US + EU + Asia sites appears in each corresponding region ranking. Filtering is derived from each CDMO's declared facility locations.
| # | CDMO | Signal Score | Quality | FDA · GMP | Capacity | Programs |
|---|---|---|---|---|---|---|
| 1 |
CR
Charles River Laboratories
Newbury Park, CA · Memphis, TN · Keele, UK · Rockville, MD
|
91.7 | 98.7 | 8 insp · 11 GMP | Limited | 0 programs |
| 2 |
PC
Pfizer CentreOne
Kalamazoo, MI · McPherson, KS
|
91.5 | 100.0 | 4 insp · 17 GMP | — | 363 programs |
| 3 |
BMS
Bristol Myers Squibb (CGT Mfg)
Bothell, WA · Warren, NJ
|
90.8 | 97.0 | 6 insp · 2 GMP | — | 581 programs |
| 4 |
PB
Pharmaron Biologics
San Diego, CA · Shaoxing, China, Liverpool, UK, Ningbo China
|
86.9 | 100.0 | 3 insp · 0 GMP | Available | 0 programs |
| 5 |
AJ
Ajinomoto Bio-Pharma Services
San Diego, CA · Osaka, JP
|
85.6 | 100.0 | 0 insp · 1 GMP | — | 0 programs |
| 6 |
AE
Aldevron
Fargo, ND
|
85.3 | 100.0 | 1 insp · 0 GMP | — | 0 programs |
| 7 |
COH
City of Hope (T Cell Manufacturing)
Duarte, CA
|
83.8 | 96.8 | 3 insp · 0 GMP | — | 211 programs |
| 8 |
LB
Lotte Biologics
Incheon, KR · Syracuse, NY
|
83.7 | 100.0 | 1 insp · 0 GMP | — | 0 programs |
| 9 |
PR
Piramal Pharma Solutions
Lexington, KY · Riverview, MI · Ahmedabad, IN
|
83.6 | 95.7 | 5 insp · 13 GMP | — | 0 programs |
| 10 |
KB
KBI Biopharma
Durham, NC · Boulder, CO
|
83.5 | 100.0 | 1 insp · 1 GMP | Limited | 0 programs |
| 11 |
FD
FUJIFILM Diosynth Biotechnologies
Research Triangle, NC · Holly Springs, NC · Hillerod, DK
|
83.5 | 100.0 | 0 insp · 23 GMP | 0 programs | |
| 12 |
MN
Minaris Advanced Therapies
Philadelphia, PA · Allendale, NJ · Munich, DE · Yokohama, JP
|
83.5 | 100.0 | 1 insp · 6 GMP | Limited | 0 programs |
| 13 |
TF
Thermo Fisher Scientific
Plainville, MA · Alachua, FL · Cambridge, MA
|
83.1 | 97.9 | 5 insp · 10 GMP | Available | 2 programs |
| 14 |
CD
Corden Pharma
Plankstadt, DE · Caponago, IT · Boulder, CO
|
82.5 | 99.7 | 3 insp · 10 GMP | — | 0 programs |
| 15 |
MR
Moderna (Contract Mfg)
Norwood, MA
|
81.8 | 100.0 | 2 insp · 4 GMP | — | 10 programs |
| 16 |
MK
Merck KGaA / MilliporeSigma (CDMO)
Darmstadt, DE · St. Louis, MO
|
81.8 | 98.6 | 2 insp · 2 GMP | — | 22 programs |
| 17 |
WK
Wacker Biotech
Jena, DE · Amsterdam, NL · San Diego, CA
|
81.6 | 100.0 | 0 insp · 13 GMP | — | 0 programs |
| 18 |
EF
Eurofins CDMO
Planegg, DE · San Diego, CA
|
81.6 | 100.0 | 5 insp · 0 GMP | — | 0 programs |
| 19 |
DH
Danaher (CGT Portfolio)
Washington, DC
|
81.5 | — | — | — | 0 programs |
| 20 |
EK
Evonik Health Care
Birmingham, AL · Vancouver, BC
|
81.5 | 99.8 | 2 insp · 2 GMP | — | 0 programs |
| 21 |
BR
BioReliance (Merck)
Glasgow, UK · Rockville, MD
|
81.0 | 98.8 | 4 insp · 8 GMP | — | 0 programs |
| 22 |
AV
Avid Bioservices
Tustin, CA
|
80.8 | 100.0 | 1 insp · 0 GMP | — | 0 programs |
| 23 |
NW
Northway Biotech
Vilnius, LT; Waltham (MA), USA
|
80.8 | 100.0 | 0 insp · 8 GMP | Available | 0 programs |
| 24 |
MedPharm (Tergus Pharma)
Guildford UK, Durham NC
|
80.8 | 100.0 | 1 insp · 0 GMP | Available | 0 programs |
| 25 |
AG
AGC Biologics
Longmont, CO · Milan, IT · Copenhagen, DK · Chiba, JP
|
80.6 | 99.9 | 2 insp · 23 GMP | Available | 2 programs |
| 26 |
TK
Takeda
Boston, MA · Zurich, CH
|
80.5 | 99.3 | 4 insp · 18 GMP | — | 100 programs |
| 27 |
ND
Nitto Denko Avecia
Milford, MA
|
80.3 | 100.0 | 2 insp · 0 GMP | — | 0 programs |
| 28 |
RC
RoslinCT
Edinburgh, UK · Hopkinton, MA
|
80.2 | 98.8 | 1 insp · 1 GMP | Available | 0 programs |
| 29 |
GS
GenScript ProBio
Piscataway, NJ · Nanjing, CN
|
79.5 | 100.0 | — | Constrained | 0 programs |
| 30 |
CRA
Curia (RNA/Advanced)
Albany, NY · Albuquerque, NM
|
79.4 | 99.9 | 2 insp · 16 GMP | — | 0 programs |
| 31 |
BY
Bayer (Cell Therapy Mfg)
Berkeley, CA
|
79.2 | 86.9 | 8 insp · 17 GMP | — | 125 programs |
| 32 |
NV
Novartis Contract Manufacturing
Morris Plains, NJ · Stein, CH
|
79.1 | 90.9 | — | Constrained | 284 programs |
| 33 |
CS
Cedars-Sinai Biomanufacturing
Los Angeles, CA
|
78.9 | 100.0 | 1 insp · 0 GMP | — | 34 programs |
| 34 |
BB
bluebird bio Manufacturing
Durham, NC
|
78.5 | — | — | — | 0 programs |
| 35 |
GP
Green Phoenix Labs
San Diego, CA
|
78.1 | 100.0 | 0 insp · 1 GMP | — | 0 programs |
| 36 |
CK
Codiak BioSciences (Sarepta)
Cambridge, MA
|
78.0 | 100.0 | 1 insp · 0 GMP | — | 16 programs |
| 37 |
AG2
August Bioservices
San Carlos, CA
|
77.4 | 98.5 | 1 insp · 0 GMP | — | 0 programs |
| 38 |
AF
Afton Scientific
Charlottesville, VA
|
76.8 | 100.0 | 0 insp · 1 GMP | — | 0 programs |
| 39 |
FH
Fred Hutch Cell Therapy Lab
Seattle, WA
|
76.4 | — | — | — | 452 programs |
| 40 |
KD
Kindeva Drug Delivery
Woodbury, MN
|
75.9 | 98.0 | 2 insp · 3 GMP | — | 0 programs |
| 41 |
CI
Cincinnati Children's Vector Production Facility
Cincinnati, OH
|
75.2 | 100.0 | 1 insp · 0 GMP | — | 1 programs |
| 42 |
CA
Catalent (Novo Holdings)
Harmans, MD · Gosselies, BE
|
75.1 | 79.3 | 1 insp · 0 GMP | Available | 0 programs |
| 43 |
AL
Agilent Technologies (Oligo GMP)
Santa Clara, CA
|
74.2 | 100.0 | 2 insp · 0 GMP | — | 1 programs |
| 44 |
CG
Cytiva (Mfg Services)
Marlborough, MA · Uppsala, SE
|
74.0 | — | — | — | 0 programs |
| 45 |
NR
National Resilience
San Diego, CA · Boston, MA · RTP, NC · Philadelphia, PA
|
73.4 | 97.7 | 1 insp · 0 GMP | Available | 9 programs |
| 46 |
LZ
Lonza Biologics
Houston, TX · Portsmouth, NH · Geleen, NL · Basel, CH
|
72.8 | 95.1 | 1 insp · 0 GMP | Limited | 0 programs |
| 47 |
VE
Vigene Biosciences
Rockville, MD
|
72.5 | — | — | — | 0 programs |
| 48 |
TL
TriLink BioTechnologies
San Diego, CA
|
71.0 | — | — | — | 0 programs |
| 49 |
EM
Emergent BioSolutions (CGT)
Baltimore, MD
|
71.0 | — | — | — | 4 programs |
| 50 |
IO
Iovance Biotherapeutics (Mfg)
Philadelphia, PA
|
70.8 | — | — | — | 30 programs |
| 51 |
GZ
Genezen
Indianapolis, IN · Lexington, MA
|
70.7 | 84.1 | 3 insp · 0 GMP | Available | 0 programs |
| 52 |
GM
Grand River Aseptic Manufacturing
Grand Rapids, MI
|
66.4 | 75.5 | 3 insp · 0 GMP | — | 0 programs |
| 53 |
GenScript
Piscataway, NJ
|
65.5 | — | — | — | 0 programs |
| 54 |
AT
Arcturus Therapeutics (Mfg)
San Diego, CA
|
65.5 | — | — | — | 0 programs |
| 55 |
PP
PolyPeptide Group
Torrance, CA · Strasbourg, FR · Malmo, SE
|
64.8 | 70.9 | 3 insp · 0 GMP | — | 0 programs |
| 56 |
Abzena
San Diego, CA; Bristol, PA; Cambridge, UK
|
64.0 | — | — | Available | 0 programs |
| 57 |
AN
Andelyn Biosciences
Columbus, OH
|
63.0 | — | — | Available | 0 programs |
| 58 |
CT
CTMC
Houston, TX
|
63.0 | — | — | — | 0 programs |
| 59 |
UM
MassBiologics
Boston, MA
|
63.0 | — | 1 insp · 0 GMP | — | 0 programs |
| 60 |
LG
LGC Biosearch Technologies
Petaluma, CA · Middleton, WI
|
63.0 | — | — | — | 0 programs |
| 61 |
FB
Forge Biologics
Columbus, OH
|
62.7 | — | — | 3 programs | |
| 62 |
MX
MaxCyte
Gaithersburg, MD
|
62.0 | — | — | — | 0 programs |
| 63 |
CL
Cellares
South San Francisco, CA
|
61.5 | — | — | Available | 0 programs |
| 64 |
MS
Made Scientific
Princeton, NJ
|
61.5 | — | — | — | 0 programs |
| 65 |
GF
GeneFab
Alameda, CA and South San Francisco
|
61.5 | — | — | Available | 0 programs |
| 66 |
Cytovance Biologics
Oklahoma City, OK
|
61.5 | — | — | Available | 0 programs |
| 67 |
Catachem Inc.
Oxford, CT
|
61.5 | — | — | 0 programs | |
| 68 |
KC
Kincell Bio
Research Triangle Park, NC
|
60.5 | — | — | — | 0 programs |
| 69 |
UB
uBriGene Biosciences
Shanghai, CN · Boston, MA
|
60.5 | — | — | — | 0 programs |
| 70 |
AP
Applied StemCell
Milpitas, CA
|
60.5 | — | — | — | 0 programs |
| 71 |
AB
Asklepios BioPharmaceutical (AskBio)
Research Triangle, NC · San Sebastian, ES
|
59.7 | — | — | — | 10 programs |
| 72 |
MA
Matica Biotechnology
College Station, TX
|
59.0 | — | — | Available | 0 programs |
| 73 |
VB
VintaBio
Cambridge, MA
|
59.0 | — | — | — | 0 programs |
| 74 |
WB
Waisman Biomanufacturing
Madison, WI
|
59.0 | — | — | — | 0 programs |
| 75 |
EB
ElevateBio BaseCamp
Waltham, MA
|
59.0 | — | — | — | 0 programs |
| 76 |
C3
C3i Center
Houston, TX
|
59.0 | — | — | — | 0 programs |
| 77 |
BN
Bionova Scientific
Fremont, CA
|
59.0 | — | — | — | 0 programs |
| 78 |
AS
Artis BioSolutions
Lake Nona, FL
|
59.0 | — | — | — | 0 programs |
| 79 |
VM
Vector BioMed
Cambridge, MA
|
59.0 | — | — | — | 0 programs |
| 80 |
PO
Poseida Therapeutics (CDMO)
San Diego, CA
|
58.7 | — | — | — | 6 programs |
| 81 |
TG
ThermoGenesis
Rancho Cordova, CA
|
57.8 | — | — | — | 1 programs |
| 82 |
NE
Nature Technology
Lincoln, NE
|
56.5 | — | — | — | 0 programs |
| 83 |
VX
VGXI
The Woodlands, TX
|
56.5 | — | — | — | 0 programs |
| 84 |
CU
Culture Biosciences
South San Francisco, CA
|
56.5 | — | — | — | 0 programs |
| 85 |
HB
Hongene Biotech
Union City, CA
|
56.5 | — | — | — | 0 programs |
| 86 |
BS
Bio-Synthesis Inc.
Lewisville, TX
|
56.5 | — | — | — | 0 programs |
| 87 |
CG2
ChemGenes Corporation
Wilmington, MA
|
56.5 | — | — | — | 0 programs |
| 88 |
MM
Mermade (BioAutomation)
Irving, TX
|
56.5 | — | — | — | 0 programs |
| 89 |
GR
Glen Research
Sterling, VA
|
56.5 | — | — | — | 0 programs |
| — |
Ritedose Corporation
Columbia, SC
|
Profiled | — | — | — | 0 programs |
| — |
Kite Pharma (Gilead Sciences)
Santa Monica, CA
|
Profiled | — | — | — | 0 programs |
| — |
Rose BioSolutions
Wilmington, MA
|
Profiled | — | — | — | 0 programs |
| — |
Orphan Therapeutics Accelerator (OTXL)
Cambridge, MA
|
Profiled | — | — | — | 0 programs |
| — |
Pyramid Pharma Services (Pyramid Laboratories, Inc.)
Costa Mesa, CA
|
Profiled | — | — | — | 0 programs |
| — |
TriRx Pharmaceutical Services
Norwalk, CT
|
Profiled | — | — | — | 0 programs |
| — |
Formulated Solutions
Largo, FL
|
Profiled | — | — | — | 0 programs |
| — |
Cellipont Bioservices
The Woodlands, TX
|
Profiled | — | — | — | 0 programs |
| — |
AmbioPharm
North Augusta, SC
|
Profiled | — | — | — | 0 programs |
| — |
PCI Pharma Services
Philadelphia, PA
|
Profiled | — | — | — | 0 programs |
| — |
Bryllan LLC
Brighton, MI
|
Profiled | — | — | — | 0 programs |
| — |
CPC Scientific
Sunnyvale, CA
|
Profiled | — | — | — | 0 programs |
| — |
Argonaut Manufacturing Services
Carlsbad, CA
|
Profiled | — | — | — | 0 programs |
| — |
Evergreen Theragnostics
Springfield, NJ
|
Profiled | — | — | — | 0 programs |
| — |
NorthStar Medical Radioisotopes
Beloit, WI
|
Profiled | — | — | — | 0 programs |
| — |
Bend Bioscience
Bend, OR
|
Profiled | — | — | — | 0 programs |
| — |
Codis
St. Louis, MO (UK site: Haverhill, Suffolk, UK)
|
Profiled | — | — | — | 0 programs |
| — |
Serán Bioscience
Bend, OR
|
Profiled | — | — | — | 0 programs |
| — |
DPT Laboratories
San Antonio, TX
|
Profiled | — | 1 insp · 0 GMP | — | 0 programs |
| — |
UPM Pharmaceuticals
Bristol, TN
|
Profiled | — | — | — | 0 programs |
| — |
Veranova
Devens, MA
|
Profiled | — | — | — | 0 programs |
| — |
Porton Advanced
Cranbury, NJ
|
Profiled | — | — | — | 0 programs |
| — |
Mikart LLC
Atlanta, GA
|
Profiled | — | — | — | 0 programs |
| — |
Eurofins Advantar Laboratories, LLC
San Diego, CA
|
Profiled | — | — | — | 0 programs |
| — |
Vantage Vector (Demo)
Gaithersburg, MD
|
Profiled | — | — | Available | 0 programs |
| — |
Cambrex Corporation
East Rutherford, NJ
|
Profiled | — | — | — | 0 programs |
| — |
Phillips Medisize
Hudson, WI
|
Profiled | — | — | — | 0 programs |
| — |
Advanced BioScience Laboratories, Inc. (ABL Inc.)
Rockville, MD
|
Profiled | — | — | — | 0 programs |
| — |
Nucleus RadioPharma
Rochester, MN
|
Profiled | — | — | — | 0 programs |
| — |
Full Circles Therapeutics
San Francisco, CA
|
Profiled | — | — | — | 0 programs |
| — |
Ultragenyx (UX111 — AAV, Sanfilippo Syndrome Type A)
Novato, CA
|
Profiled | — | — | — | 0 programs |
| — |
FUJIFILM Cellular Dynamics (FCDI)
Madison, WI
|
Profiled | — | — | — | 0 programs |
| — |
Forma Life Sciences
Irvine, CA
|
Profiled | — | — | — | 0 programs |
| — |
Scorpius BioManufacturing
San Diego, CA
|
Profiled | — | — | — | 0 programs |
| — |
Landmark Bio
Watertown, MA
|
Profiled | — | — | — | 0 programs |
| — |
Celsis® (Charles River Laboratories)
Wilmington, MA (parent: Charles River Laboratories)
|
Profiled | — | — | — | 0 programs |
| — |
American Injectables
Brooksville, FL
|
Profiled | — | — | — | 0 programs |
| — |
Navigate BioPharma Services, Inc.
Carlsbad, CA
|
Profiled | — | — | — | 0 programs |
| — |
iBio (FastPharming / iBio CDMO LLC)
Bryan, TX (historic CDMO facility); current corporate pivot to San Diego, CA
|
Profiled | — | — | — | 0 programs |
| — |
Kentucky Bioprocessing (KBP)
Owensboro, KY
|
Profiled | — | — | — | 0 programs |
| — |
Pharmaloz Manufacturing
Lebanon, PA
|
Profiled | — | — | — | 0 programs |
| — |
nanoComposix (Fortis Life Sciences)
San Diego, CA
|
Profiled | — | — | — | 0 programs |
| — |
Phosphorex
Hopkinton, MA
|
Profiled | — | — | — | 0 programs |
| — |
Woodstock Sterile Solutions
Woodstock, IL
|
Profiled | — | — | — | 0 programs |
| — |
Integrated DNA Technologies (IDT)
Coralville, IA
|
Profiled | — | — | — | 0 programs |
| — |
SpectronRx
Reno, NV (US HQ); operations in US and Europe across 5 locations)
|
Profiled | — | — | — | 0 programs |
| — |
Corden Pharma (Colorado site / formerly AmbioPharm combined)
Boulder, CO
|
Profiled | — | — | — | 0 programs |
| — |
InGeneron, Inc.
Houston, TX
|
Profiled | — | — | — | 0 programs |
| — |
Wheeler Bio
Oklahoma City, OK
|
Profiled | — | — | — | 0 programs |
| — |
Alcami
Wilmington, NC
|
Profiled | — | — | — | 0 programs |
| — |
Sharp Services
Allentown, PA
|
Profiled | — | — | — | 0 programs |
| — |
Sharp Services (Sharp Sterile Manufacturing)
Allentown, PA
|
Profiled | — | — | — | 0 programs |
| — |
LSNE Contract Manufacturing (now part of PCI Pharma Services)
Bedford, NH (acquired by PCI Pharma Services in 2021; formerly headquartered in Bedford, New Hampshire)
|
Profiled | — | — | — | 0 programs |
| — |
Dow Development Laboratories (DDL)
Petaluma, CA
|
Profiled | — | — | — | 0 programs |
| — |
Vici Health Sciences
Groton, CT
|
Profiled | — | — | — | 0 programs |
FDA jurisdiction — how the ranking scores US-based CDMOs
The Signal Score's Quality Compliance pillar (35% of the composite) is dominated by FDA inspection data for US-based CDMOs: Establishment Inspection Report classifications (NAI, VAI, OAI), Form 483 observation counts, and Warning Letter history. For a CDMO whose primary facility footprint is US, this pillar carries direct weight — an inspection on the site slated for a sponsor's program applies without translation. For CDMOs with mixed US + international facility footprint, the ranking reflects the composite regulatory posture; sponsors evaluating for a specific program should verify inspection history on the exact US site under consideration via that CDMO's profile page.
Which US CDMOs also cover EU and UK regulatory geographies?
Many top-tier US-based CDMOs maintain EU (EMA) and UK (MHRA) GMP certification for facilities used to supply EU and UK trials or commercial markets. The Signal Score's Quality Compliance pillar includes EMA + MHRA certificate density as a component — a US-headquartered CDMO with dense EU/UK certificates typically ranks higher on this pillar than a US-only competitor. Sponsors running dual-jurisdiction programs should cross-check the individual CDMO profile pages for specific certificate coverage; the Europe region ranking surfaces CDMOs that also appear in the European jurisdiction ranking, indicating multi-region regulatory posture.
How CDMO Signal identifies US manufacturing presence
Region attribution is derived from each CDMO's declared facility locations in our directory. A CDMO's facility list is validated against corporate filings, press releases, and — where public — the FDA facility registration (FEI number lookups). Region matching is done at the country level: a US state name or two-letter abbreviation in the facility list places the CDMO in the US region. CDMOs with US + international sites appear in every applicable region ranking, which reflects operational reality — such a CDMO is a legitimate candidate for programs in any of those jurisdictions.
Browse by modality within United States
Modality-specific rankings for United States-manufactured programs. Each page filters the modality's global ranking to CDMOs with confirmed United States facilities.
Other regions