Best CDMOs in United States — Ranked by Signal Score · 2026
· updated as new inspection, certificate, and trial data enters the platform
85
CDMOs in region
85
Fully scored
39
With FDA records
102
FDA inspections
214
EMA/MHRA GMP certs
CDMO Signal tracks 85 biopharma CDMOs with confirmed United States manufacturing facilities, of which 85 are fully scored across the four-pillar composite Signal Score. Across all modalities, Pfizer CentreOne, Bristol Myers Squibb (CGT Mfg), and Charles River Laboratories lead the United States ranking by composite score. Signal Score integrates FDA inspection history, EMA/MHRA GMP certificate density, ClinicalTrials.gov sponsor footprint, and monitored capacity signals. For modality-specific rankings within United States — AAV, cell therapy, biologics, and 10 other tracked modalities — see the modality-region breakdown below. Full methodology at cdmosignal.com/methodology.
US-based CDMOs ranked by CDMO Signal's composite Signal Score, filtered to manufacturers with confirmed United States facilities. This ranking is the subset of our global directory with US manufacturing presence — a CDMO with US + EU + Asia sites appears in each corresponding region ranking. Filtering is derived from each CDMO's declared facility locations.
| # | CDMO | Signal Score | Quality | FDA · GMP | Capacity | Programs |
|---|---|---|---|---|---|---|
| 1 |
PC
Pfizer CentreOne
Kalamazoo, MI · McPherson, KS
|
91.5 | 100.0 | 4 insp · 17 GMP | — | 366 programs |
| 2 |
BMS
Bristol Myers Squibb (CGT Mfg)
Bothell, WA · Warren, NJ
|
91.1 | 97.9 | 6 insp · 2 GMP | — | 585 programs |
| 3 |
CR
Charles River Laboratories
Newbury Park, CA · Memphis, TN · Keele, UK · Rockville, MD
|
90.9 | 98.3 | 8 insp · 11 GMP | Limited | 0 programs |
| 4 |
PB
Pharmaron Biologics
San Diego, CA · Shaoxing, China, Liverpool, UK, Ningbo China
|
86.9 | 100.0 | 3 insp · 0 GMP | Available | 0 programs |
| 5 |
FD
FUJIFILM Diosynth Biotechnologies
Research Triangle, NC · Holly Springs, NC · Hillerod, DK
|
84.8 | 100.0 | 0 insp · 23 GMP | 0 programs | |
| 6 |
AE
Aldevron
Fargo, ND
|
84.8 | 100.0 | 1 insp · 0 GMP | — | 0 programs |
| 7 |
KB
KBI Biopharma
Durham, NC · Boulder, CO
|
84.4 | 99.1 | 1 insp · 1 GMP | Limited | 0 programs |
| 8 |
COH
City of Hope (T Cell Manufacturing)
Duarte, CA
|
83.9 | 97.1 | 3 insp · 0 GMP | — | 213 programs |
| 9 |
AJ
Ajinomoto Bio-Pharma Services
San Diego, CA · Osaka, JP
|
83.5 | 100.0 | 0 insp · 1 GMP | — | 0 programs |
| 10 |
MN
Minaris Advanced Therapies
Philadelphia, PA · Allendale, NJ · Munich, DE · Yokohama, JP
|
83.3 | 99.6 | 1 insp · 6 GMP | Limited | 0 programs |
| 11 |
PR
Piramal Pharma Solutions
Lexington, KY · Riverview, MI · Ahmedabad, IN
|
83.3 | 95.0 | 5 insp · 13 GMP | — | 0 programs |
| 12 |
TK
Takeda
Boston, MA · Zurich, CH
|
81.9 | 99.6 | 4 insp · 18 GMP | — | 100 programs |
| 13 |
MR
Moderna (Contract Mfg)
Norwood, MA
|
81.8 | 100.0 | 2 insp · 4 GMP | — | 10 programs |
| 14 |
MK
Merck KGaA / MilliporeSigma (CDMO)
Darmstadt, DE · St. Louis, MO
|
81.8 | 98.7 | 2 insp · 2 GMP | — | 22 programs |
| 15 |
WK
Wacker Biotech
Jena, DE · Amsterdam, NL · San Diego, CA
|
81.6 | 100.0 | 0 insp · 13 GMP | — | 0 programs |
| 16 |
LB
Lotte Biologics
Incheon, KR · Syracuse, NY
|
81.6 | 100.0 | 1 insp · 0 GMP | — | 0 programs |
| 17 |
EF
Eurofins CDMO
Planegg, DE · San Diego, CA
|
81.6 | 100.0 | 5 insp · 0 GMP | — | 0 programs |
| 18 |
DH
Danaher (CGT Portfolio)
Washington, DC
|
81.5 | — | — | — | 0 programs |
| 19 |
EK
Evonik Health Care
Birmingham, AL · Vancouver, BC
|
81.5 | 99.8 | 2 insp · 2 GMP | — | 0 programs |
| 20 |
CD
Corden Pharma
Plankstadt, DE · Caponago, IT · Boulder, CO
|
81.1 | 98.9 | 4 insp · 10 GMP | — | 0 programs |
| 21 |
TF
Thermo Fisher Scientific
Plainville, MA · Alachua, FL · Cambridge, MA
|
81.0 | 100.0 | 6 insp · 10 GMP | Available | 2 programs |
| 22 |
AV
Avid Bioservices
Tustin, CA
|
80.8 | 100.0 | 1 insp · 0 GMP | — | 0 programs |
| 23 |
NW
Northway Biotech
Vilnius, LT; Waltham (MA), USA
|
80.8 | 100.0 | 0 insp · 8 GMP | Available | 0 programs |
| 24 |
BY
Bayer (Cell Therapy Mfg)
Berkeley, CA
|
80.4 | 90.1 | 8 insp · 18 GMP | — | 126 programs |
| 25 |
RC
RoslinCT
Edinburgh, UK · Hopkinton, MA
|
80.3 | 99.0 | 1 insp · 1 GMP | Available | 0 programs |
| 26 |
ND
Nitto Denko Avecia
Milford, MA
|
80.3 | 100.0 | 3 insp · 0 GMP | — | 0 programs |
| 27 |
BR
BioReliance (Merck)
Glasgow, UK · Rockville, MD
|
80.2 | 97.1 | 4 insp · 8 GMP | — | 0 programs |
| 28 |
NV
Novartis Contract Manufacturing
Morris Plains, NJ · Stein, CH
|
79.9 | 93.1 | 1 insp · 0 GMP | Constrained | 284 programs |
| 29 |
CS
Cedars-Sinai Biomanufacturing
Los Angeles, CA
|
79.8 | 100.0 | 1 insp · 0 GMP | — | 34 programs |
| 30 |
GS
GenScript ProBio
Piscataway, NJ · Nanjing, CN
|
79.5 | 100.0 | — | Constrained | 0 programs |
| 31 |
CRA
Curia (RNA/Advanced)
Albany, NY · Albuquerque, NM
|
79.4 | 99.9 | 2 insp · 18 GMP | — | 0 programs |
| 32 |
UM
MassBiologics
Boston, MA
|
79.0 | 97.2 | 1 insp · 0 GMP | — | 0 programs |
| 33 |
AG
AGC Biologics
Longmont, CO · Milan, IT · Copenhagen, DK · Chiba, JP
|
78.6 | 100.0 | 2 insp · 23 GMP | Available | 2 programs |
| 34 |
Cytovance Biologics
Oklahoma City, OK
|
78.6 | 98.1 | 1 insp · 0 GMP | Available | 0 programs |
| 35 |
BB
bluebird bio Manufacturing
Durham, NC
|
78.5 | — | — | — | 0 programs |
| 36 |
GP
Green Phoenix Labs
San Diego, CA
|
78.1 | 100.0 | 0 insp · 1 GMP | — | 0 programs |
| 37 |
CK
Codiak BioSciences (Sarepta)
Cambridge, MA
|
78.0 | 100.0 | 1 insp · 0 GMP | — | 16 programs |
| 38 |
AG2
August Bioservices
San Carlos, CA
|
77.5 | 98.7 | 1 insp · 0 GMP | — | 0 programs |
| 39 |
AF
Afton Scientific
Charlottesville, VA
|
76.8 | 100.0 | 0 insp · 1 GMP | — | 0 programs |
| 40 |
FH
Fred Hutch Cell Therapy Lab
Seattle, WA
|
76.3 | — | — | — | 454 programs |
| 41 |
KD
Kindeva Drug Delivery
Woodbury, MN
|
76.0 | 98.2 | 2 insp · 3 GMP | — | 0 programs |
| 42 |
CI
Cincinnati Children's Vector Production Facility
Cincinnati, OH
|
75.2 | 100.0 | 1 insp · 0 GMP | — | 1 programs |
| 43 |
NR
National Resilience
San Diego, CA · Boston, MA · RTP, NC · Philadelphia, PA
|
74.5 | 98.0 | 1 insp · 0 GMP | Available | 9 programs |
| 44 |
AL
Agilent Technologies (Oligo GMP)
Santa Clara, CA
|
74.2 | 100.0 | 2 insp · 0 GMP | — | 1 programs |
| 45 |
CG
Cytiva (Mfg Services)
Marlborough, MA · Uppsala, SE
|
74.0 | — | — | — | 0 programs |
| 46 |
CA
Catalent (Novo Holdings)
Harmans, MD · Gosselies, BE
|
73.1 | 74.9 | 1 insp · 0 GMP | Available | 0 programs |
| 47 |
LZ
Lonza Biologics
Houston, TX · Portsmouth, NH · Geleen, NL · Basel, CH
|
73.0 | 95.7 | 1 insp · 0 GMP | Limited | 0 programs |
| 48 |
VE
Vigene Biosciences
Rockville, MD
|
72.5 | — | — | — | 0 programs |
| 49 |
GZ
Genezen
Indianapolis, IN · Lexington, MA
|
71.5 | 85.8 | 3 insp · 0 GMP | Available | 0 programs |
| 50 |
TL
TriLink BioTechnologies
San Diego, CA
|
71.0 | — | — | — | 0 programs |
| 51 |
EM
Emergent BioSolutions (CGT)
Baltimore, MD
|
71.0 | — | — | — | 4 programs |
| 52 |
IO
Iovance Biotherapeutics (Mfg)
Philadelphia, PA
|
70.8 | — | — | — | 31 programs |
| 53 |
GM
Grand River Aseptic Manufacturing
Grand Rapids, MI
|
66.6 | 78.1 | 3 insp · 0 GMP | — | 0 programs |
| 54 |
PP
PolyPeptide Group
Torrance, CA · Strasbourg, FR · Malmo, SE
|
66.1 | 74.2 | 3 insp · 0 GMP | — | 0 programs |
| 55 |
AT
Arcturus Therapeutics (Mfg)
San Diego, CA
|
65.5 | — | — | — | 0 programs |
| 56 |
AN
Andelyn Biosciences
Columbus, OH
|
63.0 | — | — | Available | 0 programs |
| 57 |
CT
CTMC
Houston, TX
|
63.0 | — | — | — | 0 programs |
| 58 |
LG
LGC Biosearch Technologies
Petaluma, CA · Middleton, WI
|
63.0 | — | — | — | 0 programs |
| 59 |
AB
Asklepios BioPharmaceutical (AskBio)
Research Triangle, NC · San Sebastian, ES
|
61.8 | — | — | — | 10 programs |
| 60 |
GF
GeneFab
Alameda, CA and South San Francisco
|
61.5 | — | — | Available | 0 programs |
| 61 |
FB
Forge Biologics
Columbus, OH
|
61.2 | — | — | 3 programs | |
| 62 |
MA
Matica Biotechnology
College Station, TX
|
59.0 | — | — | Available | 0 programs |
| 63 |
CL
Cellares
South San Francisco, CA
|
59.0 | — | — | Available | 0 programs |
| 64 |
VB
VintaBio
Cambridge, MA
|
59.0 | — | — | — | 0 programs |
| 65 |
MS
Made Scientific
Princeton, NJ
|
59.0 | — | — | — | 0 programs |
| 66 |
WB
Waisman Biomanufacturing
Madison, WI
|
59.0 | — | — | — | 0 programs |
| 67 |
EB
ElevateBio BaseCamp
Waltham, MA
|
59.0 | — | — | — | 0 programs |
| 68 |
MX
MaxCyte
Gaithersburg, MD
|
59.0 | — | — | — | 0 programs |
| 69 |
C3
C3i Center
Houston, TX
|
59.0 | — | — | — | 0 programs |
| 70 |
BN
Bionova Scientific
Fremont, CA
|
59.0 | — | — | — | 0 programs |
| 71 |
AS
Artis BioSolutions
Lake Nona, FL
|
59.0 | — | — | — | 0 programs |
| 72 |
VM
Vector BioMed
Cambridge, MA
|
59.0 | — | — | — | 0 programs |
| 73 |
AP
Applied StemCell
Milpitas, CA
|
59.0 | — | — | — | 0 programs |
| 74 |
Vantage Vector (Demo)
Gaithersburg, MD
|
59.0 | — | — | Available | 0 programs |
| 75 |
PO
Poseida Therapeutics (CDMO)
San Diego, CA
|
58.7 | — | — | — | 6 programs |
| 76 |
TG
ThermoGenesis
Rancho Cordova, CA
|
57.8 | — | — | — | 1 programs |
| 77 |
KC
Kincell Bio
Research Triangle Park, NC
|
56.5 | — | — | — | 0 programs |
| 78 |
UB
uBriGene Biosciences
Shanghai, CN · Boston, MA
|
56.5 | — | — | — | 0 programs |
| 79 |
NE
Nature Technology
Lincoln, NE
|
56.5 | — | — | — | 0 programs |
| 80 |
VX
VGXI
The Woodlands, TX
|
56.5 | — | — | — | 0 programs |
| 81 |
CU
Culture Biosciences
South San Francisco, CA
|
56.5 | — | — | — | 0 programs |
| 82 |
BS
Bio-Synthesis Inc.
Lewisville, TX
|
56.5 | — | — | — | 0 programs |
| 83 |
CG2
ChemGenes Corporation
Wilmington, MA
|
56.5 | — | — | — | 0 programs |
| 84 |
MM
Mermade (BioAutomation)
Irving, TX
|
56.5 | — | — | — | 0 programs |
| 85 |
GR
Glen Research
Sterling, VA
|
56.5 | — | — | — | 0 programs |
FDA jurisdiction — how the ranking scores US-based CDMOs
The Signal Score's Quality Compliance pillar (35% of the composite) is dominated by FDA inspection data for US-based CDMOs: Establishment Inspection Report classifications (NAI, VAI, OAI), Form 483 observation counts, and Warning Letter history. For a CDMO whose primary facility footprint is US, this pillar carries direct weight — an inspection on the site slated for a sponsor's program applies without translation. For CDMOs with mixed US + international facility footprint, the ranking reflects the composite regulatory posture; sponsors evaluating for a specific program should verify inspection history on the exact US site under consideration via that CDMO's profile page.
Which US CDMOs also cover EU and UK regulatory geographies?
Many top-tier US-based CDMOs maintain EU (EMA) and UK (MHRA) GMP certification for facilities used to supply EU and UK trials or commercial markets. The Signal Score's Quality Compliance pillar includes EMA + MHRA certificate density as a component — a US-headquartered CDMO with dense EU/UK certificates typically ranks higher on this pillar than a US-only competitor. Sponsors running dual-jurisdiction programs should cross-check the individual CDMO profile pages for specific certificate coverage; the Europe region ranking surfaces CDMOs that also appear in the European jurisdiction ranking, indicating multi-region regulatory posture.
How CDMO Signal identifies US manufacturing presence
Region attribution is derived from each CDMO's declared facility locations in our directory. A CDMO's facility list is validated against corporate filings, press releases, and — where public — the FDA facility registration (FEI number lookups). Region matching is done at the country level: a US state name or two-letter abbreviation in the facility list places the CDMO in the US region. CDMOs with US + international sites appear in every applicable region ranking, which reflects operational reality — such a CDMO is a legitimate candidate for programs in any of those jurisdictions.
Browse by modality within United States
Modality-specific rankings for United States-manufactured programs. Each page filters the modality's global ranking to CDMOs with confirmed United States facilities.
AAV / Gene Therapy (32)
CAR-T (16)
Lentiviral Vector (21)
Cell Therapy (31)
mRNA / LNP (18)
Plasmid DNA (13)
Biologics / mAb (18)
Oligonucleotide / ASO (12)
Adenoviral Vector (3)
Gene Editing (9)
Exosome / Extracellular Vesicle (1)
Recombinant Proteins (9)
ADC (Antibody-Drug Conjugate) (4)
Gene Therapy (35)
Cell & Gene Therapy (56)
Viral Vector (35)