Adenoviral Vector CDMOs — Ranked by Signal Score

CDMOs tracked

Fully scored

With FDA records

FDA inspections

EMA/MHRA GMP certs

Adenoviral vector CDMOs make replication-deficient adenovirus for gene therapy and vaccines, using producer cell lines (e.g. HEK293), suspension bioreactors, and chromatographic purification. The platform reaches high titers, which suits vaccine-scale demand.

Selecting an adenoviral CDMO turns on serotype and producer-line experience, suspension scale, full/empty particle control, and a clean regulatory record. The rankings below score each CDMO on FDA inspections, GMP certification, clinical activity, and capacity.

FDA inspection outcomes across these CDMOs: 1 NAI (no action), 3 VAI (voluntary action), 0 OAI (official action). Leading inspection & GMP sites: UNITED KINGDOM (10), United States (4), Belgium (4), Italy (4), Ireland (1).

Last updated 2026-05-22. Sourced from FDA, EMA EudraGMDP, MHRA GMDP, and ClinicalTrials.gov.

#	CDMO	Signal Score	Quality	FDA · GMP	Capacity	Programs
1	TF Thermo Fisher Scientific Plainville, MA · Alachua, FL · Cambridge, MA	83.1	97.9	4 insp · 10 GMP	Available	2 programs
2	ET Exothera Jumet, BE	78.1	100.0	0 insp · 4 GMP	—	0 programs
3	AD Advent Bioservices London, UK	78.1	100.0	0 insp · 2 GMP	—	0 programs
4	VE Vigene Biosciences Rockville, MD	72.5	—	—	—	0 programs
5	RT ReiThera Rome, IT	71.1	100.0	0 insp · 4 GMP	—	1 programs
6	EM Emergent BioSolutions (CGT) Baltimore, MD	71.0	—	—	—	4 programs
—	3P Biopharmaceuticals (now 3PBIOVIAN) Pamplona-Noáin, Spain	Profiled	—	—	—	0 programs
—	CoJourney Inc. Ambler, PA (US operations; primary manufacturing in Hangzhou, Zhejiang, China)	Profiled	—	—	—	0 programs
—	Rose BioSolutions San Francisco, CA (GI Partners parent); East Coast operations in Rockville, MD	Profiled	—	—	—	0 programs

How we score CDMOs →

What to evaluate in a Adenoviral Vector CDMO

Producer line & serotype

Confirm experience with your serotype (Ad5 and others) and producer cell line, and whether the process is suspension-adapted for scale.

Scale & titer

Adenovirus reaches high titers for vaccine-scale demand. Match validated bioreactor scale to your dose and volume.

Particle quality

Full/empty particle ratio and aggregate control affect potency and safety. Ask about the analytics package.

Regulatory track record

Cross-check FDA 483 history and EMA/MHRA GMP coverage — both shown above and on each profile.

Adenoviral Vector CDMOs — Frequently Asked Questions

Who are the top Adenoviral Vector CDMOs?

By CDMO Signal's independent Signal Score, the top-ranked Adenoviral Vector CDMOs include Thermo Fisher Scientific, Exothera, Advent Bioservices. See the full ranked table above — scored on FDA, clinical, financial, and capacity data.

How many Adenoviral Vector CDMOs have FDA inspection records?

CDMO Signal tracks 1 Adenoviral Vector CDMO with FDA inspection records and 20 EMA/MHRA GMP certificates across the group.

What should I look for in an adenoviral vector CDMO?

Confirm serotype and producer-line experience, a suspension process at your required scale, strong particle-quality analytics, and a clean FDA and EMA/MHRA record.

How is adenoviral vector manufacturing different from AAV?

Both are non-enveloped viral vectors made in HEK293-type lines, but adenovirus is larger and drives strong transient expression (suiting vaccines), while AAV is the workhorse for durable in vivo gene therapy.

Related modalities

AAV / Gene Therapy CDMOs Gene Editing CDMOs Cell Therapy CDMOs

Other Modalities

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